12/31/2023 0 Comments Carbon dioxide formula massRitter, Chemical & Engineering News, 90(22), May 28, 2012. Pharma Strives for Green Goals, Stephen K. “ Green Chemistry in the Redesign of the Sertraline Process” and Professor Yi Tang, University of California, Los Angeles “ An Efficient Biocatalytic Process to Manufacture Simvastatin”Ģ002 PGCCA Winner: Pfizer, Inc. So, it is important to extend the impressive results achieved by the ACS GCIPR to all parts of the drug industry, especially the biopharma and generic sectors, as well as to other sectors of the chemical enterprise where synthetic chemistry is used to produce their products.Ģ012 PGCCA Winner: Codexis, Inc. However, when companies apply green chemistry principles to the design of the API process, dramatic reductions in waste are often achieved, sometimes as much as ten-fold. This is an important roundtable focus because of the historically large amount of waste coproduced during drug manufacturing-more than 100 kilos per kilo of API in many cases. More recently, the ACS Green Chemistry Institute Pharmaceutical Roundtable ( ACS GCIPR) has favored process mass intensity, which expresses a ratio of the weights of all materials (water, organic solvents, raw materials, reagents, process aids) used to the weight of the active drug ingredient (API) produced. My view is the first principle, often referred to as the prevention principle, is the most important and the other principles are the “how to’s” to achieve itĪn often-used measure of waste is the E-factor, described by Roger Sheldon, which relates the weight of waste coproduced to the weight of the desired product. In their publication “ Green Chemistry, Theory and Practice” in 1998, Anastas and Warner introduced their 12 principles. Cue, Jr., Ph.D., BWC Pharma Consulting, LLC. It is better to prevent waste than to treat or clean up waste after it has been created.Ĭontributed by Berkeley W.
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